When it comes to allergic reactions, anaphylaxis is the nightclub bouncer of the lot. Mean, big, nasty, and notorious for not playing around. It bullies multiple parts of your body simultaneously, without a defining signature move. It could mess with your breathing, make your face swell up like a balloon, or throw up an unprovoked skin unrest. All because your immune system freaks out and sends an army of chemicals into your body, seeing a harmless intruder as a full-blown Death Star.

No one can precisely pin why some unwelcome food, particular medication, or a species of venom tickles your immune system the wrong way. But hey, it's not a who-done-it; it's more about understanding what you're allergic to, avoiding the nasties, and nailing down the response the moment anaphylaxis gatecrashes your life.

Generally, you become allergic to a jerk allergen through exposure - that could be a one-off face-to-face, or a long-term sparring match. There's no telling when you might cop an anaphylactic uppercut from a previously harmless substance. But there are a few pointers - like increased chances of anaphylaxis if you’re sensitive to more routine allergies or have asthma or cardiovascular disease.

In the grand scheme of anaphylaxis risk factors, men are more likely to suffer from insect venom-induced anaphylaxis, while women get a worse deal from latex, aspirin, and certain imaging scan mediums.

Food allergies, especially peanuts, are the terror bullies for kids, while adults need to watch out for rogue antibiotics, injectables, and anesthetics. The sweeping generalization is, anaphylaxis can pimp-slap you, courtesy of anything you're allergic to - typically, food, meds, latex, or insect venom. Certain activities like jogging or exercising in extreme weather also play villain.

In short, when it comes to anaphylaxis, the gloves are off. Understanding the ropes won't make you Ronda Rousey, but it'll arm you to make smart decisions for your health and that's one hell of an upper hand.