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Swallow Bitter Pills or Fatty Liver: Unmasking Aspirin's Unknown Boons

health

By Owen M.

- Mar 25, 2024

You thought aspirin, your go-to for headaches, fever, and body aches, couldn't get any cooler? Well, brace yourself for a surprise: this commonplace cure may well be dropping its mic in the fight against nonalcoholic steatohepatitis (or simply soda-induced fatty liver disease).

Dubbed as "metabolic dysfunction–associated steatotic liver disease" (MASLD) in fancier circles, this liver glutton binges on excess body fat like a guilt-free holiday feast, igniting an unwelcome inflammation party in your liver. Brace yourselves though, because this is where the unassuming aspirin pill sashays into the scene.

Playing the lottery with 80 adults armed with liver-filled fats, scientists bravely bestowed 81 milligrams (mg) of aspirin (or "baby aspirin") or a shallow placebo to each participant for six months. The scorecard? An impressive average fat reduction of 6.6 percent from that tiny aspirin versus a disappointing 3.6 percent fat gain by the placebo pretender.

Digging deeper exposes that about 43 percent of these brave aspirin aficionados saw their liver fat levels nosedive by a whopping 30 percent. Digest that for a moment: an everyday, cheap-as-chips aspirin just might be your liver's new best friend.

Unwrapping the mystery behind its wizardry, aspirin apparently moonlights as a pro-inflammatory blockade in the liver, effectively reversing its fat and inflammation status –a conclusion that even Harvard Medical School and the Massachusetts General Hospital's own Tracey Simon, MD, MPH, can affirm.

So far, aspirin’s logged an impressive résumé - combating liver fat, inflammation, and scarring, while skillfully dodging serious complications of advanced MASLD like liver cancer and knife-worthy scars known as cirrhosis. Quite impressive for a household drug, isn't it?

The downside, because there always is one, reside in some side effects like upper respiratory tract infections and joint stiffness experienced by a third of the participants. Yet, despite this little setback and the research's size and brevity, the notion of aspirin being an inconspicuous weapon against liver fat continues to gain ground.

However, don’t go gulping down baby aspirins just yet. This isn’t an invitation to empty your local pharmacy’s aspirin aisle. Current research is too early-stage for doctors to prescribe it as a fatty liver panacea. But hold onto that excitement folks because this game-changing anti-fat pill brings a new ray of hope for livers out there crying out for a fat-free liberation.

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