Psychosis: A term that strikes a chord, generally triggering images of a horrifying disconnect with reality. It’s characterized by delusions, hallucinations, and if it were a dish at your fancy, overpriced hipster restaurant, it would probably be the chef's special, featured in the 'Schizophrenia à la Carte'. Unfortunately, it also barge gates other mental landscapes, like major depression, being the obnoxious party crasher that it is. It’s even the rude guest that shows up uninvited after brain injuries and substance abuse.

Hold up – take a deep breath. This isn't the plot of a horror movie, merely 3% of the population experiencing an episode of psychosis at some point in their lives. Let's dial down the drama a touch: psychosis isn't a standalone condition but more of an unpleasant symptom that piggybacks on psychiatric or medical conditions.

Imagine psychosis as your overbearing, paranoid friend who insists that what they're seeing and hearing is real, while the rest of the world steadily insists, 'Nah, not quite.' This distortion of reality can be a one-hit wonder, can have a longer playtime, or may prefer a Kris Kross 'Jump' style comeback, causing recurring symptoms.

Psychosis defines itself by two main features:

1. Delusions: Holders of false beliefs, even in the face of invalidating evidence.
2. Hallucinations: The sensation or perceived sensation of something that is not present.

Plus, there can be diagnostic accessories that help differentiate whether the cause is psychiatric, medical, or as glamorous as substance-related. Keep in mind, psychosis likes to mix things up – both in its manifestations and causes.

The chameleon-like trait of psychosis allows it to morph and become a defining feature of conditions labeled under 'Schizophrenia Spectrum and Other Psychotic Disorders' in DSM-5, AKA the 'Psychiatrist's Bible.' Embarking on this spectrum of disorders, you'll come across schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, to name a few.

Psychosis is also an opportunistic gatecrasher, popping up at times when other mental disorders are partying hard, creating chaos instead of celebrating. That guest list includes mental disorders like major depression, bipolar disorder, PTSD, or even substance-induced disorders.

Now, let's not farm all psychotic blame on psychiatric conditions. Introducing, medical conditions: the secret backdoor through which psychosis sneaks into reality. Creative little disruptor, isn't it? A brain injury, a stroke, encephalopathy, dementia, Parkinson’s disease could have psychosis as their uninvited plus one.

And just when you thought you'd heard it all, let's mix in a cocktail of psychoactive substances that can kickstart a psychotic episode – because why not? This can happen as a result of a Friday-night-gone-wrong, long-term use, or the dreaded drug withdrawal period.

Treatment, you ask? Well, that depends on the kind of party psychosis is crashing. Medication, therapy, or both may be used. So, while your medical caboose rattles out antipsychotic drugs that help bring symptoms under control, psychotherapy comes in to do the cleaning up. And let's not forget the new kid on the block, Cobenfy, making a fresh attempt to improve positive and negative symptoms caused by schizophrenia.